Enpp1 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comEnpp1 Polyclonal Antibody for Mouse(Mus musculus)

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Enpp1 (Gene name),

Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Protein name ), ENPP1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Enpp1(Npps;Pc1;Pdnp1);

Protein name:

Ectonucleotide pyrophosphatase/phosphodiesterase family member 1(E-NPP 1);

Alternative:

Phosphodiesterase I/nucleotide pyrophosphatase 1;Lymphocyte antigen 41(Ly-41);Plasma-cell membrane glycoprotein PC-1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer; disulfide-linked.

Function:

Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity.

Subcellular Location:

Membrane Single-pass type II membrane protein Basolateral cell membrane Single-pass type II membrane protein Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts. In bile duct cells and cancer cells, located to the apical cytoplasmic side.

Protein Attributes:

Sequence length:

906

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

906:

IFSQED

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P06802

Pfam:

PF01223

UniGene:

Mm.27254

SMR:

P06802

Uniprot:

P06802

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ELISA Kit for Mouse E-NPP 1

Cat.:

E1032r

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96T

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ELISA Kit for Mouse E-NPP 1

Cat.:

E1032h

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96T

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ELISA Kit for Mouse E-NPP 1

Cat.:

E1032m

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Packing:

96T

CLIA Kit for Mouse E-NPP 1

Cat.:

U1032h

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96T

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CLIA Kit for Mouse E-NPP 1

Cat.:

U1032m

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MSDS:

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96T

CLIA Kit for Mouse E-NPP 1

Cat.:

U1032r

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96T

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Polyclonal Antibody for Mouse E-NPP 1

Cat.:

P1032Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse E-NPP 1

Cat.:

P1032Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse E-NPP 1

Cat.:

P1032Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse E-NPP 1

Protein for Mouse E-NPP 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Plasma cell membrane glycoprotein PC-1. Primary structure deduced from cDNA clones."
van Driel I.R. , Goding J.W.
J. Biol. Chem.262:4882-4887(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TOPOLOGY;SUBUNIT
strain: BALB/c.
2.

Goding J.W.
Submitted (2001-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 24; 46-47; 642 AND 693
3.

"Identification of nucleotide pyrophosphatase/alkaline phosphodiesterase I activity associated with the mouse plasma cell differentiation antigen PC-1."
Rebbe N.F. , Tong B.D. , Finley E.M. , Hickman S.
Proc. Natl. Acad. Sci. U.S.A.88:5192-5196(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];GLYCOSYLATION;FUNCTION;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION
strain: BALB/c.
tissue: Plasmacytoma.
4.

"Structural basis of allotypes of ecto-nucleotide pyrophosphatase/phosphodiesterase (plasma cell membrane glycoprotein PC-1) in the mouse and rat, and analysis of allele-specific xenogeneic antibodies."
Banakh I. , Sali A. , Dubljevic V. , Grobben B. , Slegers H. , Goding J.W.
Eur. J. Immunogenet.29:307-313(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANTS ARG-651 AND SER-680;ALTERNATIVE SPLICING
5.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: NOD.
tissue: Thymus.
6.

"Identification and characterization of a soluble form of the plasma cell membrane glycoprotein PC-1 (5'-nucleotide phosphodiesterase)."
Belli S.I. , van Driel I.R. , Goding J.W.
Eur. J. Biochem.217:421-428(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 168-188;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;GLYCOSYLATION
7.

"Murine plasma cell membrane antigen PC-1: molecular cloning of cDNA and analysis of expression."
van Driel I.R. , Wilks A.F. , Pietersz G.A. , Goding J.W.
Proc. Natl. Acad. Sci. U.S.A.82:8619-8623(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 203-219
8.

"The murine plasma cell antigen PC-1: purification and partial amino acid sequence."
Stearne P.A. , van Driel I.R. , Grego B. , Simpson R.J. , Goding J.W.
J. Immunol.134:443-448(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 204-219; 332-351; 486-509; 716-725; 803-818 AND 855-867;SUBCELLULAR LOCATION
9.

"Plasma cell membrane glycoprotein PC-1. cDNA cloning of the human molecule, amino acid sequence, and chromosomal location."
Buckley M.F. , Loveland K.A. , McKinstry W.J. , Garson O.M. , Goding J.W.
J. Biol. Chem.265:17506-17511(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF POSSIBLE INITIATION SITE
10.

"Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine."
Okawa A. , Nakamura I. , Goto S. , Moriya H. , Nakamura Y. , Ikegawa S.
Nat. Genet.19:271-273(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE;FUNCTION
11.

"Structural and catalytic similarities between nucleotide pyrophosphatases/phosphodiesterases and alkaline phosphatases."
Gijsbers R. , Ceulemans H. , Stalmans W. , Bollen M.
J. Biol. Chem.276:1361-1368(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVE SITE;METAL-BINDING;MUTAGENESIS OF ASP-200; LYS-237; THR-238; PHE-239; ASP-358; HIS-362; ASP-405; HIS-406 AND HIS-517;CATALYTIC ACTIVITY
12.

"Characterization of a di-leucine-based signal in the cytoplasmic tail of the nucleotide-pyrophosphatase NPP1 that mediates basolateral targeting but not endocytosis."
Bello V. , Goding J.W. , Greengrass V. , Sali A. , Dubljevic V. , Lenoir C. , Trugnan G. , Maurice M.
Mol. Biol. Cell12:3004-3015(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DI-LEUCINE MOTIF;MUTAGENESIS OF ALA-28; SER-30; LEU-31 AND LEU-32;SUBCELLULAR LOCATION
13.

"Subcellular targeting and function of osteoblast nucleotide pyrophosphatase phosphodiesterase 1."
Vaingankar S.M. , Fitzpatrick T.A. , Johnson K. , Goding J.W. , Maurice M. , Terkeltaub R.
Am. J. Physiol.286:C1177-C1187(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DI-LEUCINE MOTIF;MUTAGENESIS OF LEU-31; LEU-32; LEU-42 AND TYR-57;SUBCELLULAR LOCATION
14.

"The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
Gundry R.L. , Raginski K. , Tarasova Y. , Tchernyshyov I. , Bausch-Fluck D. , Elliott S.T. , Boheler K.R. , Van Eyk J.E. , Wollscheid B.
Mol. Cell. Proteomics8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-267; ASN-323 AND ASN-624
tissue: Myoblast.
15.

"Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling."
Kato K. , Nishimasu H. , Okudaira S. , Mihara E. , Ishitani R. , Takagi J. , Aoki J. , Nureki O.
Proc. Natl. Acad. Sci. U.S.A.109:16876-16881(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 92-906 IN COMPLEXES WITH AMP; CMP; GMP; TMP; CALCIUM AND ZINC;GLYCOSYLATION AT ASN-267; ASN-323 AND ASN-567;DISULFIDE BOND;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;MUTAGENESIS OF PHE-239; HIS-242; 304-TRP--ASN-323; ASP-308 AND TYR-322;COFACTOR
16.

"Structure of NPP1, an ectonucleotide pyrophosphatase/ phosphodiesterase involved in tissue calcification."
Jansen S. , Perrakis A. , Ulens C. , Winkler C. , Andries M. , Joosten R.P. , Van Acker M. , Luyten F.P. , Moolenaar W.H. , Bollen M.
Structure20:1948-1959(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 87-906 IN COMPLEX WITH CALCIUM; PHOSPHATE AND ZINC;DISULFIDE BONDS;METAL-BINDING SITES;SUBUNIT;SUBCELLULAR LOCATION;GLYCOSYLATION AT ASN-323; ASN-459; ASN-567 AND ASN-624;COFACTOR

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